Identification and < em > α < /em > -glucosidase inhibitory activity evaluation of two new coumarins derived from < em > Mansonia gagei < /em > J. R. Drumm

Nat Prod Res. 2024 Feb 29:1-6. doi: 10.1080/14786419.2024.2324367. Online ahead of print.ABSTRACTFive coumarins were isolated from the heartwood of Mansonia gagei, which included two newly discovered compounds, namely 11-hydroxypopulene E (1) and mansorin D (2), along with three previously identified compounds. The structures were determined through the utilisation of comprehensive spectroscopic data, ECD calculations, and a thorough comparison with existing literature data. The α-glucosidase inhibitory activities of all isolated compounds were assessed in yeast. Out of the compounds tested, compound 2 exhibited the most significant activity, displaying a percentage inhibition of 34.33% at a concentration of 200 μM.PMID:38422455 | DOI:10.1080/14786419.2024.2324367

Source: Natural Product Research - February 29, 2024 Category: Biochemistry Authors: Huong Thi Thu Le Yusuke Hioki Duy Vu Nguyen Thi-Kim-Dung Le Van-Kieu Nguyen Tien T Dang Thi-Anh-Tuyet Nguyen Thi-Hoai-Thu Nguyen Thi-Hai-Duyen Vu Thi-Kim-Ngan Pham Masaki Kita Warinthorn Chavasiri Source Type: research