Novel Approach for Pancreas Transcriptomics Reveals the Cellular Landscape in Homeostasis and Acute Pancreatitis

Digestive enzymes impede single-cell profiling of exocrine pancreas. FixNCut uses reversible fixation to overcome this challenge, allowing us to define cell heterogeneity and dynamic cell states during pancreatitis and establish an acinar-to-ductal metaplasia index.

Source: Gastroenterology - February 5, 2024 Category: Gastroenterology Authors: Katherine J. Aney, Woo-Jeong Jeong, Andres F. Vallejo, Cassandra Burdziak, Ethan Chen, Austin Wang, Pal Koak, Kellie Wise, Kirk Jensen, Dana Pe ’er, Stephanie K. Dougan, Luciano Martelotto, Sahar Nissim Tags: Basic and Translational - Pancreas Source Type: research