Role of recovery of acetylcholine release in compromised neuromuscular junction function

Walking, breathing, and eating are examples of essential human activities that are enabled by repetitive skeletal muscle contractions under control of the nervous system. During contractions of increasing intensity, activation frequency is increased and more motor units are recruited in order of smallest to largest (known as the size principle) to produce enough force to enable movement. In functional movement, such as walking, the same motor units will be activated repeatedly, and each singular contraction require repeated excitations of skeletal muscle fibres within the motor unit.

Source: Neuromuscular Disorders - January 23, 2024 Category: Neurology Authors: Jeppe Blichfeldt Winther, Jeanette Jeppesen Morgen, Martin Skov, Martin Gruwier Broch-Lips, Ole B ækgaard Nielsen, Kristian Overgaard, Thomas Holm Pedersen Source Type: research