Manganese(I)-Catalyzed C –H Allylation of Tryptophans and Their Oligopeptides On Water

Synlett DOI: 10.1055/a-2268-4678 The manganese(I)-catalyzed allylation of the amino acid tryptophan is realized under exceedingly mild conditions using water as a sustainable and non-hazardous reaction medium, instead of classical organic solvents, with great potential for green and sustainable chemistry. Synthetically useful α,β-unsaturated esters can be accessed by reaction with Morita–Baylis–Hillman (MBH) adducts following a fast C–H activation approach. The robustness of this procedure is reflected by kinetic analysis at different reaction temperatures and reduced catalyst loadings are employed. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - February 27, 2024 Category: Chemistry Authors: Struwe, Julia Oyama, Tsuyoshi Gallou, Fabrice Ackermann, Lutz Tags: letter Source Type: research