The importance of Spin-Polarized Charge Reorganization in the Catalytic Activity of D-Glucose Oxidase

Chemphyschem. 2024 Feb 27:e202400033. doi: 10.1002/cphc.202400033. Online ahead of print.ABSTRACTThe reaction of D-glucose oxidase (GOx) with D- and L-glucose was investigated using confocal fluorescence microscopy and Hall voltage, after the enzyme was adsorbed as a monolayer. By adsorbing the enzyme on a ferromagnetic substrate, we verified that the reaction is spin dependent. This conclusion was supported by monitoring the reaction when the enzyme is adsorbed on a Hall device that does not contain any magnetic elements. The spin dependence is consistent with the chiral-induced spin selectivity (CISS) effect; it can be explained by the improved fidelity of the electron transfer process through the chiral enzyme due to the coupling of the linear momentum of the electrons and their spin. Since the reaction studies often serve as a model system for enzymatic activity, the results may suggest the general importance of the spin-dependent electron transfer in bio-chemical processes.PMID:38411033 | DOI:10.1002/cphc.202400033

Source: Chemphyschem - February 27, 2024 Category: Chemistry Authors: Naupada Preeyanka Qirong Zhu Tapan-Kumar Das Ron Naaman Source Type: research