TSLP is localized in and released from human lung macrophages activated by T2-high and T2-low stimuli: relevance in asthma and COPD

CONCLUSIONS: Our results highlight a novel immunologic circuit between HLMs and TSLP. Given the central role of macrophages in airway inflammation, this autocrine loop holds potential translational relevance in understanding innovative aspects of the pathobiology of asthma and chronic inflammatory lung disorders.PMID:38402021 | DOI:10.1016/j.ejim.2024.02.020

Source: European Journal of Internal Medicine - February 24, 2024 Category: Internal Medicine Authors: Luisa Can è Remo Poto Francesco Palestra Marinella Pirozzi Seetharaman Parashuraman Ilaria Iacobucci Anne Lise Ferrara Antonello La Rocca Edoardo Mercadante Piero Pucci Gianni Marone Maria Monti Stefania Loffredo Gilda Varricchi Source Type: research