TSLP is localized in and released from human lung macrophages activated by T2-high and T2-low stimuli: relevance in asthma and COPD
CONCLUSIONS: Our results highlight a novel immunologic circuit between HLMs and TSLP. Given the central role of macrophages in airway inflammation, this autocrine loop holds potential translational relevance in understanding innovative aspects of the pathobiology of asthma and chronic inflammatory lung disorders.PMID:38402021 | DOI:10.1016/j.ejim.2024.02.020
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Luisa Can รจ Remo Poto Francesco Palestra Marinella Pirozzi Seetharaman Parashuraman Ilaria Iacobucci Anne Lise Ferrara Antonello La Rocca Edoardo Mercadante Piero Pucci Gianni Marone Maria Monti Stefania Loffredo Gilda Varricchi Source Type: research