Characterization of human CD4 < sup > + < /sup > EOMES < sup > + < /sup > GzmK < sup > + < /sup > T-cell subsets unveils an uncoupling of suppressive functions from IL-10-producing capacities

Eur J Immunol. 2024 Feb 23:e2350675. doi: 10.1002/eji.202350675. Online ahead of print.ABSTRACTHuman CD4+ EOMES+ T cells are heterogeneous and contain Th1-cells, Tr1-cells, and CD4+ CTL. Tr1- cells and non-classical EOMES+ Th1-cells displayed, respectively, anti- and pro-inflammatory cytokine profiles, but both expressed granzyme-K, produced IFN-γ, and suppressed T-cell proliferation. Diffusion map suggested a progressive CD4+ T-cell differentiation from naïve to cytotoxic cells and identified EOMES+ Th1-cells as putative Tr1-cell precursors (pre-Tr1).PMID:38396108 | DOI:10.1002/eji.202350675

Source: European Journal of Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Nadia Pulvirenti Ylenia Silvetri Francesca Clemente Roberto Bosotti Elena Carelli Giorgia Moschetti Paola Gruarin Chiara Vasco Maria Cristina Crosti Maria Lucia Sarnicola Luca Valenti Daniele Prati Sergio Abrignani Jens Geginat Source Type: research