ONE SHOT - single shot radiotherapy for localized prostate cancer: 18-month results of a single arm, multicenter phase I/II trial

Total dose and dose per fraction play an important role in optimizing the curative treatment of prostate cancer with external beam radiotherapy (EBRT). In the last decade, based on radiobiological modeling showing a low α/β ratio (i.e., ∼ 1.5 Gy) for prostate cancer cells [1], moderate hypofractionated EBRT (i.e., dose per fraction 2.5 Gy to 4 Gy) has largely been adopted in the clinical practice with the attempt to potentially increase the tumor cell killing effect with relatively less toxicity on the su rrounding late responding normal tissues.

Source: Radiotherapy and Oncology - February 23, 2024 Category: Radiology Authors: THOMAS ZILLI, CIRO FRANZESE, MATTHIAS GUCKENBERGER, NICCOL Ò GIAJ-LEVRA, NICOLAS MACH, NIKOLAOS KOUTSOUVELIS, VERANE ACHARD, ANDREW MCDONALD, FILIPPO ALONGI, MARTA SCORSETTI, GUILLAUME CONSTANTIN, AURELIE BERTAUT, RAYMOND MIRALBELL Tags: Original Article Source Type: research