SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences

Trends Immunol. 2024 Feb;45(2):81-84. doi: 10.1016/j.it.2024.01.003. Epub 2024 Jan 31.ABSTRACTSARS-CoV-2 is continuously evolving. The Omicron subvariant BA.2.86, with >30 mutations in its spike (S) protein compared with its predecessor strain BA.2, was expected to quickly become predominant worldwide, but this has not happened. Instead, its descendant strain, JN.1, with just one additional mutation, has become the predominant SARS-CoV-2 subvariant. Here, we offer a possible explanation for these unexpected consequences.PMID:38302341 | DOI:10.1016/j.it.2024.01.003
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Source Type: research