Proactive therapeutic monitoring of dalbavancin concentrations in the long-term management of chronic osteoarticular/periprosthetic joint infections

Antimicrob Agents Chemother. 2024 Feb 22:e0002324. doi: 10.1128/aac.00023-24. Online ahead of print.ABSTRACTHere, we describe the use of proactive therapeutic drug monitoring (TDM) to individualize the optimal timing of drug injections in 16 adult patients with chronic osteoarticular infections receiving a median of 7 injections of dalbavancin (up to 12 injections in 15 months). Dalbavancin injections were repeated at medians of 39-47 days, with infusion intervals ranging from 26 to 69 days. TDM can facilitates a precise, targeted use of dalbavancin for infections requiring prolonged treatments.PMID:38385700 | DOI:10.1128/aac.00023-24

Source: Antimicrobial Agents and Chemotherapy - February 22, 2024 Category: Microbiology Authors: Dario Cattaneo Marta Fusi Lucia Galli Camilla Genovese Riccardo Giorgi Maddalena Matone Stefania Merli Marta Colaneri Andrea Gori Source Type: research