Genes, Vol. 15, Pages 278: Human Leukocyte Antigen Markers for Distinguishing Pustular Psoriasis and Adult-Onset Immunodeficiency with Pustular Reaction

Genes, Vol. 15, Pages 278: Human Leukocyte Antigen Markers for Distinguishing Pustular Psoriasis and Adult-Onset Immunodeficiency with Pustular Reaction Genes doi: 10.3390/genes15030278 Authors: Apiwat Sangphukieo Patcharawadee Thongkumkoon Pitiporn Noisagul Luca Lo Piccolo Timothy E. O’Brien Suteeraporn Chaowattanapanit Charoen Choonhakarn Warayuwadee Amornpinyo Romanee Chaiwarith Salin Kiratikanon Rujira Rujiwetpongstorn Napatra Tovanabutra Siri Chiewchanvit Piranit Kantaputra Worrachet Intachai Sivamoke Dissook Mati Chuamanochan Pustular skin diseases, with pustular psoriasis (PP) being the prototype, are immune-mediated diseases characterized by the presence of multiple pustules, resulting from neutrophil accumulation in the layer of epidermis. Sterile skin pustular eruption, like PP, is also observed in 20–30% of patients with adult-onset immunodeficiency syndrome (AOID) and anti-interferon γ autoantibodies (IFN-γ), leading to challenges in classification and diagnosis. While the mechanism underlying this similar phenotype remains unknown, genetic factors in relation to the immune system are suspected of playing an important role. Here, the association between human leukocyte antigen (HLA) genes, which play essential roles in antigen presentation, contributing to immune response, and the presence of skin pustules in AOID and PP was revealed. HLA genotyping of 41 patients from multiple cen...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research