TIPE2: A Candidate for Targeting Antitumor Immunotherapy

J Immunol. 2024 Mar 1;212(5):755-763. doi: 10.4049/jimmunol.2300433.ABSTRACTTNF-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a recently discovered negative regulator of innate and adaptive immunity. TIPE2 is expressed in a wide range of tissues, both immune and nonimmune, and is implicated in the maintenance of immune homeostasis within the immune system. Furthermore, TIPE2 has been shown to play a pivotal role in the regulation of inflammation and the development of tumor. This review focuses on the structural characteristics, expression patterns, and functional roles of TIPE proteins, with a particular emphasis on the role and underlying mechanisms of TIPE2 in immune regulation and its involvement in different diseases. However, the current body of evidence is still limited in providing a comprehensive understanding of the complex role of TIPE2 in the human body, warranting further investigation to elucidate the possible mechanisms and functions of TIPE2 in diverse disease contexts.PMID:38377476 | DOI:10.4049/jimmunol.2300433
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Source Type: research