Thrombin Generation Assay in Antiphospholipid Antibodies Positive Subjects as a Personalized Thrombotic Risk Assessment: State of the Art and Perspectives

AbstractPurpose of the ReviewThrombotic risk assessment in antiphospholipid positive (aPL  +) subjects is a major challenge, and the study of in vitro thrombin generation (thrombin generation assays (TGA)) could provide useful information. Activated protein C (APC) sensitivity is involved in thrombotic events in antiphospholipid syndrome patients. We summarized methods used to assess A PC sensitivity with TGA and evaluated the prognostic role of APC resistance through literature search.Recent FindingsAPC resistance induced by aPL is a complex pathway. Several cross-sectional studies assessed APC sensitivity to understand thrombotic event mechanisms in aPL  + subjects. Only one prospective cohort had investigated the prognostic impact of APC resistance in aPL + subjects, with a positive and significant correlation between APC sensitivity and the risk of thrombosis during the follow up (hazard ratio, 6.07 [95% CI, 1.69–21.87]).SummaryAPC resistance assessed with TGA could be associated with thrombotic events in aPL  + subjects.
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research