A left-handed RNA quadruplex directs gene silencing

Trends Biochem Sci. 2024 Feb 16:S0968-0004(24)00029-X. doi: 10.1016/j.tibs.2024.01.009. Online ahead of print.ABSTRACTPoly(UG) or 'pUG' dinucleotide repeats direct gene silencing in Caenorhabditis elegans by adopting an unusual quadruplex structure. Humans have thousands of pUG sequences and proteins that interact with them. The pUG fold reveals new aspects of gene regulation and RNA folding, highlighting how a simple sequence can encode a complex structure.PMID:38368181 | DOI:10.1016/j.tibs.2024.01.009

Source: Trends in Biochemical Sciences - February 17, 2024 Category: Biochemistry Authors: Samuel E Butcher Source Type: research