Recent advancements in disulfide bridge characterization: Insights from mass spectrometry

CONCLUSIONS: This review presents the latest advancement in MS-based characterization; also a critical perspective is presented for further annotation of DSBs using MS, primarily for single purified proteins or peptides that are densely connected and rich in cysteine. Despite significant breakthroughs resulting from advancements in MS, the analysis of disulfide bonds is not straightforward; it necessitates expertise in sample preparation and interpretation.PMID:38361473 | DOI:10.1002/rcm.9713

Source: Rapid Communications in Mass Spectrometry : RCM - February 16, 2024 Category: Chemistry Authors: Sachin Chaturvedi Sanket Bawake Nitish Sharma Source Type: research