A pilot study to investigate the clinically predictive values of copy number variations detected by next generation sequencing of cell free DNA in spent culture media.

Analysis of cell free DNA in spent culture media has been identified as a non-invasive alternative to trophectoderm biopsy for PGT-A. However, the clinical value has not been well studied. We performed a pilot study with the primary interest of estimating the positive predictive value of copy number variations to predict nonviable or aneuploid embryos and investigate the false positive risk.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Assisted reproduction Source Type: research