MiR-145-5p reduced ANG II-induced ACE2 shedding and the inflammatory response in alveolar epithelial cells by targeting ADAM17 and inhibiting the AT1R/ADAM17 pathway

In conclusion, our present study demonstrates the role and mechanism of miR-145-5p in alleviating ANG II-induced acute lung injury, providing a new insight into miRNA therapy for reducing lung injury in patients with aortic dissection.PMID:38365107 | DOI:10.1016/j.ejphar.2024.176392
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research