Development of an on-site therapeutic drug monitoring method using a portable spectrometer

We report on the development of an on-site therapeutic drug monitoring (TDM) method for vancomycin (VCM) utilizing a portable spectrometer and commercially available immunoturbidimetric assay reagents designed for automated clinical chemistry analyzers. The method enables the quantification of VCM in plasma samples within 10 min, with a good correlation between the measured values and the theoretical values (r2 = 0.995). The intra and inter-day precisions were found to be below 12.5% and 17.7%, respectively. Moreover, we established a correlation between the quantitative values using this method and those measured through HPLC-UV and automated clinical chemistry analyzers, showing good reliability (R2 = 0.970 and 0.951, respectively). This method allows anyone to rapidly perform TDM at the bedside and is expected to be used to evaluate appropriate drug therapy.PMID:38358581 | DOI:10.1007/s44211-024-00513-x

Source: Anal Sci - February 15, 2024 Category: Chemistry Authors: Kenichiro Todoroki Nan Fukudo Yuto Kudoh Hajime Mizuno Jun Zhe Min Shimako Tanaka Shinya Uchida Noriyuki Namiki Toshimasa Toyo'oka Source Type: research