Niche-specific control of tissue function by regulatory T  cells-Current challenges and perspectives for targeting metabolic disease

Cell Metab. 2024 Feb 6;36(2):229-239. doi: 10.1016/j.cmet.2023.12.019. Epub 2024 Jan 12.ABSTRACTTissue regulatory T cells (Tregs) exert pivotal functions in both immune and metabolic regulation, maintaining local tissue homeostasis, integrity, and function. Accordingly, Tregs play a crucial role in controlling obesity-induced inflammation and supporting efficient muscle function and repair. Depending on the tissue context, Tregs are characterized by unique transcriptomes, growth, and survival factors and T cell receptor (TCR) repertoires. This functional specialization offers the potential to selectively target context-specific Treg populations, tailoring therapeutic strategies to specific niches, thereby minimizing potential side effects. Here, we discuss challenges and perspectives for niche-specific Treg targeting, which holds promise for highly efficient and precise medical interventions to combat metabolic disease.PMID:38218187 | DOI:10.1016/j.cmet.2023.12.019
Source: Cell Metabolism - Category: Cytology Authors: Source Type: research