Leptin induces altered differentiation of keratinocytes by inducing insulin resistance: implications for metabolic syndrome-induced resistance of psoriatic therapy

Conclusions: Leptin induces insulin resistance by upregulating SOCS3 and give rise to differentiation disorder of keratinocyte. Insulin resistance may serve as a target for anti-psoriatic therapies.PMID:38297481 | DOI:10.1080/09546634.2024.2309305

Source: Journal of Dermatological Treatment - February 1, 2024 Category: Dermatology Authors: Rui Wang Chongli Yu Zijie Tang Jie Sun Youlin Wang Zhenkai Zhao Biwen Lin Chengxin Li Source Type: research