Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands

In this study, we found that our novel morphinan-type ligands with a side chain containing a heteroatom positioned above the d-ring have binding affinity for the opioid receptors. These novel skeletons could provide unique templates with the desired side chain above the D-ring in the morphinan skeleton, and thus, potentially advance the SAR studies of morphinan ligands with the opioid receptors.PMID:38228254 | DOI:10.1016/j.bmcl.2024.129611

Source: Bioorganic and Medicinal Chemistry Letters - January 16, 2024 Category: Chemistry Authors: Kenta Maeda Tomoya Sugai Akihisa Tokuda Keita Kajino Tsuyoshi Saitoh Hiroshi Nagase Noriki Kutsumura Source Type: research