Synthesis and antimicrobial studies of cadasides analogues via on-resin esterification

Bioorg Med Chem. 2024 Feb 1;99:117601. doi: 10.1016/j.bmc.2024.117601. Epub 2024 Jan 14.ABSTRACTA series of cadasides analogues have been prepared via a combination of solid-phase peptide synthesis and solution-phase cyclization. Primary structure-activity relationship studies of cadasides have also been established and revealed the critical roles of unnatural amino acid residues, which will facilitate the further development of cadasides analogues with improved antimicrobial activities.PMID:38278098 | DOI:10.1016/j.bmc.2024.117601

Source: Bioorganic and Medicinal Chemistry - January 26, 2024 Category: Chemistry Authors: Xiangzhen Yan Chengshuo He Zhuang Li Kang Jin Source Type: research