Unlocking translational machinery for antitubercular drug development

Trends Biochem Sci. 2024 Jan 8:S0968-0004(23)00312-2. doi: 10.1016/j.tibs.2023.12.008. Online ahead of print.ABSTRACTTargeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable-GDP (EF-Tu-GDP), elongation factor thermo stable-EF-Tu (EF-Ts-EF-Tu), and elongation factor G-GDP (EF-G-GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies.PMID:38195289 | DOI:10.1016/j.tibs.2023.12.008

Source: Trends in Biochemical Sciences - January 9, 2024 Category: Biochemistry Authors: Navneet Kumar Mushtaq Ahmad Wani Chaaya Iyengar Raje Prabha Garg Source Type: research