Interplay between the transcription preinitiation complex and the +1 nucleosome

Trends Biochem Sci. 2024 Feb;49(2):145-155. doi: 10.1016/j.tibs.2023.12.001. Epub 2024 Jan 13.ABSTRACTEukaryotic transcription starts with the assembly of a preinitiation complex (PIC) on core promoters. Flanking this region is the +1 nucleosome, the first nucleosome downstream of the core promoter. While this nucleosome is rich in epigenetic marks and plays a key role in transcription regulation, how the +1 nucleosome interacts with the transcription machinery has been a long-standing question. Here, we summarize recent structural and functional studies of the +1 nucleosome in complex with the PIC. We specifically focus on how differently organized promoter-nucleosome templates affect the assembly of the PIC and PIC-Mediator on chromatin and result in distinct transcription initiation.PMID:38218671 | DOI:10.1016/j.tibs.2023.12.001

Source: Trends in Biochemical Sciences - January 13, 2024 Category: Biochemistry Authors: Xizi Chen Yanhui Xu Source Type: research