Pre-twisting for improved genome modification and miRNA targeting

Trends Biochem Sci. 2024 Jan 17:S0968-0004(24)00002-1. doi: 10.1016/j.tibs.2024.01.002. Online ahead of print.ABSTRACTTwo reports by Dhuri et al. and Oyaghire et al., respectively, show that, through installing chiral centers at the backbone of the artificial nucleic acid, peptide nucleic acid (PNA), enhanced miRNA targeting and genome modification can be achieved, with important implications in fighting cancers and β-thalassemia.PMID:38238217 | DOI:10.1016/j.tibs.2024.01.002

Source: Trends in Biochemical Sciences - January 18, 2024 Category: Biochemistry Authors: Rongguang Lu Gang Chen Source Type: research