Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review

Mini Rev Med Chem. 2024 Jan 23. doi: 10.2174/0113895575277085231123165546. Online ahead of print.ABSTRACTUsnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural modifications, and found some usnic acid derivatives to be of more potential research value. In this paper, the structural modification, biological activity and structure-activity relationship of usnic acid were reviewed to provide reference for the development of usnic acid derivatives.PMID:38265368 | DOI:10.2174/0113895575277085231123165546

Source: Mini Reviews in Medicinal Chemistry - January 24, 2024 Category: Chemistry Authors: Wen-Zhe Nie Qing-Kun Shen Zhe-Shan Quan Hong-Yan Guo Ya-Mei Li Source Type: research