Dimeric ent-kauranoids isolated from Isodon japonica var. Glaucocalyx and their anti-inflammatory activities

Fitoterapia. 2024 Jan 29;174:105840. doi: 10.1016/j.fitote.2024.105840. Online ahead of print.ABSTRACTThe phytochemical investigation of the aerial parts of Isodon japonica var. glaucocalyx afforded four undescribed (glaucocalyxin O-R, 1-4) and six known ent-kauranoids (5-10). Their structures were established using NMR and MS measurements. Compounds 1 and 2 are dimeric ent-kaurane-type diterpenoids. Moreover, the plausible biogenetic pathways for compounds 1 and 2 were proposed as Michael addition between two monomers. Eight compounds were assayed for their anti-inflammatory activity by evaluating NO production in LPS-induced RAW 267.4 cells, and compounds 7, 8 and 9 exhibited relatively remarkable anti-inflammatory activities at 10 μM.PMID:38296167 | DOI:10.1016/j.fitote.2024.105840

Source: Fitoterapia - January 31, 2024 Category: Biochemistry Authors: Ge Wang Ao-Xue Ding Guo-Qing Qin Tong Chen Xiang-Gang Hu Liu Zheng Gao-Xiang Du Wenqiong Wang Lijiang Xuan Source Type: research