A novel nomogram for predicting endoscopic remission in refractory Crohn's disease with ustekinumab administration

Rev Esp Enferm Dig. 2024 Jan 18. doi: 10.17235/reed.2024.10212/2023. Online ahead of print.ABSTRACTUstekinumab (UST) is a human IgG1 monoclonal antibody that targets to the share p40 subunit of interleukin-12(IL-12) and IL-23. Evidence has shown that UST therapy is well tolerated and effective in inducing clinical response in refractory CD(Crohn's disease) and dose escalation is effective in recapturing response in over half of the patients. However, no predictive factor has been reported to be helpful for UST treatment in clinical practice. Additionally, there were few reports about therapeutic drug monitoring (TDM) of UST administration in China due to its late launch time in Chinese market and lack of experience in clinical use. Herein, we establish and validate the first UST-trough concentrations (TCs) -related nomogram in China for predicting endoscopic remission in refractory CD to facilitate clinical decision making.PMID:38236159 | DOI:10.17235/reed.2024.10212/2023
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Authors: Source Type: research