Spatial transcriptomics reveals heterogeneity of histological subtypes between lepidic and acinar lung adenocarcinoma

CONCLUSIONS: These findings illustrate that assessing patient histological subtypes at the single-cell level is feasible. Additionally, tumour endothelial cells that express PD-L1 in stage IA LUAD suppress immune-responsive CD8+ T cells.PMID:38318637 | PMC:PMC10844893 | DOI:10.1002/ctm2.1573

Source: Genomics Proteomics ... - February 6, 2024 Category: Genetics & Stem Cells Authors: Linshan Xie Hui Kong Jinjie Yu Mengting Sun Shaohua Lu Yong Zhang Jie Hu Fang Du Qiuyu Lian Hongyi Xin Jian Zhou Xiangdong Wang Charles A Powell Fred R Hirsch Chunxue Bai Yuanlin Song Jun Yin Dawei Yang Source Type: research