Towards identification of new genetic determinants for post-weaning diarrhea in piglets

This study aimed to identify new genetic loci for resistance to diarrhea based on phenotypic data. In depth clinical characterization of diarrhea was performed in 257 pigs belonging to two herds during the first 14 days post weaning. The daily diarrhea assessments were used for the classification of pigs into case and control groups. Pigs were assigned to case and control groups based only on the incidence of diarrhea in the second week of the study in order to differentiate between differences in etiology. Genome-wide association studies and metabolomics association analysis were performed in order to identify new biological determinants for diarrhea susceptibility. With the present work, we revealed a new locus for diarrhea resistance on SSC16. Furthermore, studies of metabolomics in the same pigs revealed one metabolite associated with diarrhea.PMID:38343028 | DOI:10.1111/age.13406

Source: Animal Genetics - February 12, 2024 Category: Genetics & Stem Cells Authors: Emil Ibragimov Esben Østergaard Eriksen Jens Peter Nielsen Claus B J ørgensen Merete Fredholm Peter Karlskov-Mortensen Source Type: research