HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III

Leone and Srivastava et  al. describe the direct interaction of chaperone proteins with RNA in human cells. They describe the localization of HSP70 on genes transcribed by RNA polymerase III. HSP70 interacts with the transcribed tRNA, and this interaction alleviates the inhibitory effect of cognate tRNA transcript on tRNA gene transcription.

Source: Molecular Cell - January 23, 2024 Category: Cytology Authors: Sergio Leone, Avinash Srivastava, Andr és Herrero-Ruiz, Barbara Hummel, Lena Tittel, Roberto Campalastri, Fernando Aprile-Garcia, Jun Hao Tan, Prashant Rawat, Patrik Andersson, Anne E. Willis, Ritwick Sawarkar Tags: Article Source Type: research