A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus Curvularia aeria

Chem Pharm Bull (Tokyo). 2024;72(1):98-101. doi: 10.1248/cpb.c23-00723.ABSTRACTA novel tricyclic polyketide, curvulanone (1), was isolated from the marine-derived fungus Curvularia aeria. The structure of 1 was determined by NMR and single-crystal X-ray crystallography. 1 had a cyclopentabenzopyranone with 3-acetic acid structure that is rarely found in natural compounds. Monoamine oxidase and sirtuin 1 inhibitory test was exhibited and 1 showed their inhibitory activity.PMID:38233138 | DOI:10.1248/cpb.c23-00723

Source: Chemical and Pharmaceutical Bulletin - January 17, 2024 Category: Drugs & Pharmacology Authors: Hitoshi Kamauchi Mayu Tanaka Mitsuaki Suzuki Miho Furukawa Atsushi Ikeda Chihiro Sasho Yuka Kiba Masashi Kitamura Koichi Takao Yoshiaki Sugita Source Type: research