Physiologically based pharmacokinetic modeling to predict maternal pharmacokinetics and fetal carbamazepine exposure during pregnancy

In conclusion, this study established and validated a pregnancy PBPK model of carbamazepine and carbamazepine-10,11-epoxide to assess exposure in pregnant women and fetuses, which provided a reference for the dosage adjustment of carbamazepine during pregnancy.PMID:38244810 | DOI:10.1016/j.ejps.2024.106707

Source: European Journal of Pharmaceutical Sciences - January 20, 2024 Category: Drugs & Pharmacology Authors: Yuying Chen Meng Ke Weipeng Fang Yaojie Jiang Rongfang Lin Wanhong Wu Pinfang Huang Cuihong Lin Source Type: research