Communicating computational workflows in a regulatory environment
Drug Discov Today. 2024 Jan 12:103884. doi: 10.1016/j.drudis.2024.103884. Online ahead of print.ABSTRACTThe volume of nucleic acid sequence data has exploded recently, amplifying the challenge of transforming data into meaningful information. Processing data can require an increasingly complex ecosystem of customized tools, which increases difficulty in communicating analyses in an understandable way yet is of sufficient detail to enable informed decisions or repeats. This can be of particular interest to institutions and companies communicating computations in a regulatory environment. BioCompute Objects (BCOs; an instance of pipeline documentation that conforms to the IEEE 2791-2020 standard) were developed as a standardized mechanism for analysis reporting. A suite of BCOs is presented, representing interconnected elements of a computation modeled after those that might be found in a regulatory submission but are shared publicly - in this case a pipeline designed to identify viral contaminants in biological manufacturing, such as for vaccines.PMID:38219969 | DOI:10.1016/j.drudis.2024.103884
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Jonathon G Keeney Naila Gulzar Jack B Baker Ondrej Klempir Geoffrey D Hannigan Danny A Bitton Julia M Maritz Charles H S King Janisha A Patel Paul Duncan Raja Mazumder Source Type: research