Allogenic Vertebral Body Adherent Mesenchymal Stromal Cells Promote Muscle Recovery in Diabetic Mouse Model of Limb Ischemia
Chronic limb threatening ischemia (CLTI) is a severe limitation in perfusion of the lower extremities. CLTI carries a significant risk for amputation especially in diabetic patients with poor options for revascularization. Phase I trials have demonstrated efficacy of allogeneic mesenchymal stromal cells (MSC) in treating diabetic CLTI. Vertebral body adherent mesenchymal stromal cells (vBA-MSC) are derived from vertebral bodies of deceased organ donors which offer the distinct advantage of providing a 1,000x greater yield compared to that of living donor bone aspiration.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Mackenzie K. Madison, Theresa Doiron, Jennifer Stashevsky, Hanaa Dakour Aridi, Nancy Zhang, Chang-Hyun Gil, Steven Miller, Michael Murphy Source Type: research