Isoform-specific RNA structure determination using Nano-DMS-MaP

Nature Protocols, Published online: 12 February 2024; doi:10.1038/s41596-024-00959-3A protocol for Nano-DMS-MaP, a method for in situ isoform-specific RNA structure determination. The technique employs nanopore sequencing to resolve the structures of long and highly similar RNA molecules, revealing previously hidden structural differences.

Source: Nature Protocols - February 12, 2024 Category: Biomedical Science Authors: Anne-Sophie Gribling-Burrer Patrick Bohn Redmond P. Smyth Source Type: research