Hypothetical Assessments of Trial Emulations

To the Editor We thank Janda et al for their hypothetical assessment of whether randomized clinical trials (RCTs) submitted to regulators for supplemental indications can be emulated with secondary health care data. While we see some value in their hypothetical exercise, the proof will be in attempting actual emulations of these trials. We have completed approximately 50 actual trial emulations, and these 4 principal remarks come from our experience.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research