Pharmacologic Management of Non –Eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases

Data for pharmacologic treatments for non –eosinophilic esophagitis (EoE) eosinophilic gastrointestinal diseases (EGIDs) are limited. Nevertheless, because of the increasing understanding of EGID pathogenesis, a number of medications are used to treat EGIDs, though all are currently off-label. Initial therapy generally starts with cortico steroids, and “topical” delivery is preferred over systemic due to long-term side effects. A number of other small molecules could potentially be used, ranging from allergy medications to immunosuppressants. Biologics are also being used and investigated for EGIDs and represent promising targete d therapies. Multiple therapeutic targets have also been identified, many of which overlap with EoE targets.
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research