An AI ‐generated proteome‐scale dataset of predicted protein structures for the ctenophore Mnemiopsis leidyi

AbstractThis Dataset Brief describes the computational prediction of protein structures for the ctenophoreMnemiopsis leidyi. Here, we report the proteome-scale generation of 15,333 protein structure predictions using AlphaFold, as well as an updated implementation of publicly available search, manipulation, and visualization tools for these protein structure predictions through theMnemiopsis Genome Project Portal (https://research.nhgri.nih.gov/mnemiopsis). The utility of these predictions is demonstrated by highlighting comparisons to experimentally determined structures for the light-sensitive protein mnemiopsin 1 and the ionotropic glutamate receptor (iGluR). The application of these novel protein structure prediction methods will serve to further position non-bilaterian species such asMnemiopsis as powerful model systems for the study of early animal evolution and human health.

Source: Proteomics - February 9, 2024 Category: Biochemistry Authors: R. Travis Moreland, Suiyuan Zhang, Sofia N. Barreira, Joseph F. Ryan, Andreas D. Baxevanis Tags: DATASET BRIEF Source Type: research