Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms

JAK2 V617F is the most frequent driver mutation found in myeloproliferative neoplasms (MPNs), in approximately 50-60% of myelofibrosis (MF)1. Mutations in additional sex combs-like 1 (ASXL1), a polycomb chromatin-binding epigenetic regulator, often co-occur with JAK2 V617F and are associated with decreased survival and increased risk of transformation to secondary acute myeloid leukemia2,3. How mutant ASXL1 contributes to the MPN disease phenotype and confers poor prognosis is not fully understood.

Source: Experimental Hematology - February 8, 2024 Category: Hematology Authors: Taylor B. Collins, Angelo B.A. Laranjeira, Tim Kong, Mary C. Fulbright, Daniel A.C. Fisher, Christopher M. Sturgeon, Luis F.Z. Batista, Stephen T. Oh Tags: Brief Communication Source Type: research