Nucleophilic functionalization of thianthrenium salts under basic conditions

Abstract
In recent years, S-(alkyl)thianthrenium salts have become an important means of functionalizing alcohol compounds. However, additional transition metal catalysts and/or visible light are required. Herein, a direct thioetherification/amination reaction of thianthrenium salts is realized under metal-free conditions. This strategy exhibits good functional-group tolerance, operational simplicity, and an extensive range of compatible substrates.

Beilstein J. Org. Chem. 2024, 20, 257–263. doi:10.3762/bjoc.20.26

Source: Beilstein Journal of Organic Chemistry - February 8, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: amination functionalization of alcohol metal-free S-(alkyl)thianthrenium salts thioetherification Full Research Paper Source Type: research