Calcitriol modulates epidermal tight junction barrier function in human keratinocytes

The aberrant expression of tight junction (TJ) proteins play an important role in several diseases with impaired skin barriers, including atopic dermatitis, psoriasis, and chronic wounds. The evidence provided thus far suggests an important role of calcitriol in skin homeostasis. However, it is not known whether calcitriol improves the impaired skin barrier.

Source: Journal of Dermatological Science - February 6, 2024 Category: Dermatology Authors: Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Masahiro Nakamura, Yoshie Umehara, Hainan Yue, Risa Ikutama, Miho Takahashi, Shigaku Ikeda, Hideoki Ogawa, Ko Okumura, Fran çois Niyonsaba Source Type: research