Costimulatory Molecule CD226 Regulates Atopic Dermatitis in a Mouse Model

The present study investigated the role of CD226 in a 2,4-dinitrochlorobenzene (DNCB)-induced mouse model of atopic dermatitis (AD). The results showed that the lack of CD226 (global and CD4+ T cell-specific) significantly increased ear thickness, reddening, swelling, and scaling of the skin, as well as inflammatory cell and mast cell infiltration. qPCR results demonstrated that the mRNA expressions of AD-related inflammatory cytokines and chemokines were markedly increased in the draining lymph nodes (dLNs) and lesion ear skin tissues of global and CD4+ T cell-specific CD226-deficient mice compared with that in control mice.

Source: Journal of Investigative Dermatology - February 5, 2024 Category: Dermatology Authors: Wei Qiao, Chujun Duan, Jingchang Ma, Wei Hu, Yang Xie, Lu Yang, Tingting Wang, Shuwen Wu, Xuemei Li, Yuling Wang, Kun Cheng, Yun Zhang, Yuan Zhang, Ran Zhuang Tags: Original Article Source Type: research