WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease for which there is no curative therapy available. Repetitive alveolar epithelial injury repair, myofibroblast (MYF) accumulation and excessive collagen deposition are key pathological features of IPF, eventually leading to cellular hypoxia and respiratory failure. The precise mechanism driving this complex maladaptive process remains inadequately understood. WSB1 (WD repeat and SOCS box containing 1) is an E3 ubiquitin ligase, the expression of which is strongly associated with hypoxia, and forms a positive feedback loop with HIF-1 α under anoxic condition.

Source: American Journal of Pathology - February 5, 2024 Category: Pathology Authors: Lei Chong, Lihui Zou, Liyan Xiang, Xinyue Song, Wanqi Miao, Xihua Yan, Ming Xu, Gongxia Ling, Elie El Agha, Saverio Bellusci, Zhenkun Lou, Hailin Zhang, Jin-San Zhang Tags: Regular Article Source Type: research