Pharmacokinetics and Pharmacodynamics of Epinephrine Following Administration via Sublingual Film, Autoinjector, or Manual Injection

AQST-109, a sublingual film containing a novel prodrug of epinephrine (DESF), is under development for the emergency treatment of Type 1 allergic reactions. The final formulation of AQST-109 was compared with epinephrine delivered by two different approved autoinjectors (EpiPen and Auvi-Q) or by manual injection (IM).

Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: David Golden, Jay Lieberman, David Bernstein, John Oppenheimer, Mark Freedman, Carl Kraus, Stephen Wargacki Source Type: research