Single-cell RNA sequencing revealed that lung macrophages were composed differently depending on the asthma phenotypes.

Asthma is a heterogeneous airway inflammatory disease that is divided into eosinophilic and neutrophilic asthma. However, the immunological basis of phenotypic differences has not been elucidated. Therefore, we established a murine asthma model using different doses of lipopolysaccharide (LPS) to demonstrate that lung macrophages are distinctly modified depending on the asthma phenotype.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research