HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1 α- and TGF-β1-dependent pathway

Persons with chronic hepatitis B virus (HBV) infection coinfected with HIV experience accelerated progression of liver fibrosis compared to those with HBV mono-infection. We hypothesize that HIV and its proteins promote HBV-induced liver fibrosis in HIV/HBV coinfected cell culture models through HIF-1 α and TGF-β1 signaling.

Source: Journal of Hepatology - February 1, 2024 Category: Gastroenterology Authors: Min Xu, Charlotte Warner, Xiaoqiong Duan, Zhimeng Cheng, Andre J. Jeyarajan, Wenting Li, Yongtao Wang, Tuo Shao, Shadi Salloum, Pei-Jer Chen, Xu Yu, Raymond T. Chung, Wenyu Lin Tags: Research Article Source Type: research