MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

Abudu et  al. report that the WD-domain repeat protein MORG1 restricts mTORC1 signaling during nutrient-rich conditions, and this facilitates basal autophagy. MORG1 interacts with active Rag GTPases and inhibits the lysosomal recruitment of mTORC1. Moreover, MORG1 and p62/SQSTM1 act antagonistically on mTOR C1 activation upon amino acid withdrawal and restimulation.

Source: Molecular Cell - December 15, 2023 Category: Cytology Authors: Yakubu Princely Abudu, Athanasios Kournoutis, Hanne Britt Brenne, Trond Lamark, Terje Johansen Tags: Article Source Type: research