hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF- κB p50

Osei-Amponsa et  al. discover hRpn13 interaction with epigenetic factors physically and functionally both on and off proteasomes and contribution to NF-κB p50 production. These and additionally identified hRpn13 transcriptional requirements provide insights into its cellular impact beyond its known role at protea somes and rationale for anti-cancer activities of hRpn13 PROTACs.

Source: Molecular Cell - December 26, 2023 Category: Cytology Authors: Vasty Osei-Amponsa, Monika Chandravanshi, Xiuxiu Lu, Valentin Magidson, Sudipto Das, Thorkell Andresson, Marzena Dyba, Venkata R. Sabbasani, Rolf E. Swenson, Caroline Fromont, Biraj Shrestha, Yongmei Zhao, Michelle E. Clapp, Raj Chari, Kylie J. Walters Tags: Article Source Type: research